22-250 Remington Ammo For Sale

The .22-250 Remington is one of the most popular and effective high-velocity
varmint cartridges ever made — a blisteringly fast, flat-shooting round that has
been a favorite of dedicated varmint and predator hunters for decades. Driving
light .224-caliber bullets at tremendous speed, the .22-250 delivers a laser-flat
trajectory and explosive terminal performance on prairie dogs, coyotes, and
varmints at extended range. At Trigger Ammo Store, we carry a deep selection of
.22-250 Remington ammunition for serious varmint hunters.

What Is the 22-250 Remington?

Based on the .250 Savage case necked down to .22 caliber, the .22-250 existed
as a popular wildcat for decades before Remington standardized it in 1965. It fires
light .224-caliber bullets at very high velocity — among the fastest of the common
.22 centerfires — producing an exceptionally flat trajectory and dramatic results
on varmints. Its combination of speed, flat shooting, accuracy, and wide
availability made it one of the most beloved varmint cartridges in America, a
status it still enjoys today.

22-250 vs 220 Swift vs 223

The .22-250 sits among the top .22 centerfire varmint rounds. The
.223 Remington is more economical and versatile but slower. The
.220 Swift is the classic speed king, slightly faster than the
.22-250 at the extreme. The .22-250 hits a sweet spot — nearly
Swift-level velocity with wider ammo availability and a huge following, making it
arguably the most popular dedicated high-velocity varmint cartridge. All three are
different, non-interchangeable cartridges — match ammo to your rifle.

What Is 22-250 Good For?

Long-Range Varmint Hunting

Its blistering velocity and flat trajectory make it superb on prairie dogs,
ground squirrels, and other varmints at extended range.

Predator Hunting

Fast, explosive bullets make it deadly on coyotes and other predators — a top
fur-country choice where flat shooting matters.

High-Velocity Flat Shooting

For shooters who want maximum speed and the flattest trajectory in a widely
available .22 centerfire.

Types of 22-250 Ammo We Carry

Polymer-Tip Varmint

Fast, explosive bullets (V-MAX / Ballistic Tip-style) for dramatic terminal
performance on varmints.

Hollow Point Varmint

Rapidly-expanding bullets for small game and predators.

Soft Point

Traditional expanding loads where a bit more bullet integrity is wanted.

Common 22-250 Bullet Weights

The .22-250 is loaded with light, fast .224-caliber bullets, most commonly
35 to 64 grain. The 50–55 grain polymer-tip and
hollow-point loads are the varmint favorites — fast, flat, and explosive. Lighter
35–40 grain loads reach even higher velocities, while heavier
60–64 grain bullets buck wind better for longer shots.

Top 22-250 Ammo Brands

We stock .22-250 Remington ammunition from the manufacturers varmint hunters
trust, including Hornady, Federal, Winchester, Nosler, and Remington. From
explosive polymer-tip varmint loads to classic hollow points, you’ll find quality
options — the .22-250 enjoys wide ammo availability for a dedicated varmint
cartridge.

A Note on Barrel Life

Like other high-velocity varmint cartridges, the .22-250’s speed comes with
faster barrel wear than slower rounds, especially with sustained rapid fire during
high-volume prairie dog shoots. Letting the barrel cool between strings helps
extend its life. It’s a modest trade-off for the cartridge’s outstanding
performance, and modern barrels handle it well — a genuine consideration for
high-round-count varmint sessions, but not a concern for typical use.

Bulk 22-250 Ammo & Buying Tips

The .22-250 is a high-volume varmint caliber, so buying in quantity helps lower
your cost per round for high-round-count prairie dog trips and practice. Browse our
bulk listings for the best pricing on in-stock loads, and set a stock alert so
you’re loaded up before varmint season.

Shipping & Compliance

Orders ship quickly with secure, age-verified delivery in compliance with all
applicable federal, state, and local laws. By placing an order you confirm you are
at least 18 years of age (rifle ammunition; 21+ where required) and that it is
legal for you to purchase and receive ammunition at your delivery address. Some
states and localities restrict ammunition shipments — please review your local
regulations before ordering.

Frequently Asked Questions

What is 22-250 best for?

The .22-250 Remington is a dedicated high-velocity varmint and predator
cartridge, prized for its blistering speed and flat trajectory on prairie dogs,
coyotes, and similar small game at extended range.

Is 22-250 faster than 223?

Yes — the .22-250 drives .224 bullets significantly faster than the .223
Remington, for a flatter trajectory and more downrange energy, though the .223 is
more economical and versatile.

Do you sell 22-250 ammo in bulk?

Yes — check our bulk and case listings for the best per-round pricing on
in-stock loads.

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